P0865
Sigma
N-(3-Pyridyl)indomethacinamide
≥98%
| Synonym: | N-3PyIA, N-(3-Pyridyl)-1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetamide |
| Linear Formula: | C24H20N3O3Cl |
| Molecular Weight: | 433.89 |
| MDL number: | MFCD02683393 |
Description
| Biochem/physiol Actions | Potent and selective reversible cyclooxygenase-2 (COX-2) inhibitor (IC50 = 0.1 μM, human recombinant); about 300-fold less potent as an inhibitor of human recombinant COX-1. Not as selective with natural ovine COX (IC50 = 75 μM for COX-1 and 50 μM for COX-2). |
Properties
| assay | ≥98% |
| shipped in | wet ice |
| storage temp. | −20°C |
Safety
| Personal Protective Equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
| WGK Germany | 3 |
References
| reference | Kalgutkar, A.S., and Marnett, A.B., Ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors. J. Med. Chem. 43, 2860, (2000) |
